
Sodium
meta-periodate is a mild oxidant that is used for converting cis-glycol
groups in carbohydrates to reactive aldehyde groups. Sodium meta-periodate
cleaves bonds between adjacent carbon atoms that contain hydroxyl groups
(cis-glycols), creating two aldehyde groups that are spontaneously reactive
to amine- and hydrazide-activated labeling or cross-linking reagents. Used
in coupling to amines with cyanborohydride reduction, Sodium Meta-periodate
has rapidly increasing number of pharmaceutical applications, specially in
biomedical research.